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Oral Abstracts and Research Overview: Antiretroviral Therapy I: New Agents and New Insights

Moderator
Charles Flexner
Johns Hopkins Univ, Baltimore, MD, US

Moderator
Deborah McMahon
Univ of Pittsburgh Sch of Med, PA, US

"GS9148: A Novel Nucleotide Active Against HIV-1 Variants with Drug Resistance Mutations in Reverse Transcriptase"
Tomas Cihlar
Gilead Sci, Foster City, CA, US

"1-(�-D-Dioxolane)Thymine Is Effective Against HIV-1 Containing TAMs and M184V"
Johan Lennerstrand
Emory Univ/VA Med Ctr, Decatur, GA, US

"Nucleotide-Competing Reverse Transcriptase Inhibitors form a stable Dead-End-Complex with the HIV-1 Enzyme"
Matthias G�tte
McGill Univ, Montreal, Canada

"Next Generation HIV Peptide Fusion Inhibitor Candidates Achieve Potent, Durable Suppression of Virus Replication In Vitro and Improved Pharmacokinetic Properties"
Mary K Delmedico
Trimeris, Inc, Morrisville, NC, US

"Late Breaker COMBO: Development of Novel Orally Bioavailable CXCR4 Antagonists, KRH-3955 and KRH-3140: Binding Specificity, Pharmacokinetics, and Anti-HIV-1 Activity in vivo and in vitro"
Yuetsu Tanaka
Univ of the Ryukyus, Okinawa, Japan

"Late Breaker -- Execution of a High Throughput HIV-1 Replication Screen and the Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation"
Wade Blair
Pfizer Global Res and Devt, La Jolla, CA, US

"Towards Gene Knock Out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases"
Elena Perez
University of Pennsylvania, Philadelphia, PA

"Pharmacokinetics/Pharmacodynamics of PA-457 in a 10-Day Multiple Dose Monotherapy Trial in HIV-Infected Patients"
Patrick Smith
Univ at Buffalo Sch of Pharmacy, Buffalo, NY, US

"Research Overview: The Role of Drug Interaction Studies in Early Antiretroviral Drug Development"
Kimberly Struble
Ctr for Drug Evaluation and Res, Food and Drug Admin, Silver Spring, MD, US