Lessons Learned from In Vitro Cultivation of Hepatitis C
Takaji Wakita
Tokyo Metropolitan Inst for Neurosci, Japan

Ten Years of HAART: Principles for the Future
John G Bartlett
Johns Hopkins Univ Sch of Med, Baltimore, MD, US

Phase I-II Study of a Once-Daily Regimen of Emtricitabine, Didanosine, and Efavirenz in HIV-Infected, Therapy Naïve Children and Adolescents (PACTG Protocol 1021)
Ross McKinney
Duke Univ Sch of Med, Durham, NC, US

Three NRTI HAART Simplification in Children Is Effective in Maintaining Virological and Immunological Control after 108 Weeks
Guido Castelli-Gattinara
Bambino Gesù Children's Hosp and 2Tor Vergata Univ, Rome

Repeated Supervised Treament Interruptions with Progressive Increases in "Off-Treatment" Duration Results in Enhanced Virologic Control in a Subset of Pediatric Individuals
William Borkowsky
New York Univ Sch of Med, New York, US

Dendritic Cell Function in Surviving Children and Adolescents with Long-Term HIV Infection Acquired via Perinatal Route
Seema Desai
Univ of Miami, Miller Sch of Med, FL, US

Prevalence of Primary HIV Drug Resistance among Recently Infected Adolescents: A Multicenter Adolescent Trials Network Study (ATN029)
Rolando Viani
Univ of California, San Diego, US

Incidence of Tuberculosis in HIV-Infected Children: The Influence of Highly Active Antiretroviral Therapy
Neil Martinson
Perinatal HIV Res Unit, Univ of the Witwatersrand, South Africa

Insulin Resistance, Lipodystrophy and Associated Metabolic Changes in HIV-Infected Children
Raffaella Rosso
Univ of Genoa, San Martino Hosp, Italy

Research Overview -- The Price of Antiretroviral Therapy in Children: Focus on Metabolic Morbidities
Grace McComsey
Rainbow Babies and Children's Hosp and Case Western Reserve Univ, Cleveland, OH, US

GS9148: A Novel Nucleotide Active Against HIV-1 Variants with Drug Resistance Mutations in Reverse Transcriptase
Tomas Cihlar
Gilead Sci, Foster City, CA, US

1-(ß-D-Dioxolane)Thymine Is Effective Against HIV-1 Containing TAMs and M184V
Johan Lennerstrand
Emory Univ/VA Med Ctr, Decatur, GA, US

Nucleotide-Competing Reverse Transcriptase Inhibitors form a stable Dead-End-Complex with the HIV-1 Enzyme
Matthias Götte
McGill Univ, Montreal, Canada

Next Generation HIV Peptide Fusion Inhibitor Candidates Achieve Potent, Durable Suppression of Virus Replication In Vitro and Improved Pharmacokinetic Properties
Mary K Delmedico
Trimeris, Inc, Morrisville, NC, US

Late Breaker COMBO: Development of Novel Orally Bioavailable CXCR4 Antagonists, KRH-3955 and KRH-3140: Binding Specificity, Pharmacokinetics, and Anti-HIV-1 Activity in vivo and in vitro
Yuetsu Tanaka
Univ of the Ryukyus, Okinawa, Japan

Late Breaker -- Execution of a High Throughput HIV-1 Replication Screen and the Identification of a Novel Small Molecule Inhibitor that Targets HIV-1 Envelope Maturation
Wade Blair
Pfizer Global Res and Devt, La Jolla, CA, US

Towards Gene Knock Out Therapy for AIDS/HIV: Targeted Disruption of CCR5 Using Engineered Zinc Finger Protein Nucleases
Elena Perez
University of Pennsylvania, Philadelphia, PA

Pharmacokinetics/Pharmacodynamics of PA-457 in a 10-Day Multiple Dose Monotherapy Trial in HIV-Infected Patients
Patrick Smith
Univ at Buffalo Sch of Pharmacy, Buffalo, NY, US

Research Overview: The Role of Drug Interaction Studies in Early Antiretroviral Drug Development
Kimberly Struble
Ctr for Drug Evaluation and Res, Food and Drug Admin, Silver Spring, MD, US

Routine HIV Testing in Botswana: A Population-Based Study on Attitudes, Practices, and Human Rights Concerns
Sheri Weiser
Ctr for AIDS Prevention Studies, Univ of California, San Francisco, US

HLA-B Bw4 and Bw6 Alleles and Risk for HIV-1 Transmission in HIV-Serodiscordant Heterosexual Couples
Tania M Welzel
Natl Cancer Inst, Rockville, MD, US

Trends in HIV Diagnosis among Non-Hispanic Black Americans, 2001-2004
Tonji Durant
CDC, Atlanta, GA, US

High HIV Prevalence and Incidence Observed among African-American Men who have Sex with Men in Baltimore: The Behavioral Surveillance Research (BESURE) Study
Frangiscos Sifakis
Johns Hopkins Bloomberg Sch of Publ Hlth, Baltimore, MD, US

Non-AIDS Related Mortality Risk Exceeds AIDS-Related Mortality among Injecting Drug Users with CD4+ Counts Above 200 Cells/mm3
Bryan Lau
Johns Hopkins Univ Sch of Med, Baltimore, MD, US and Johns Hopkins Bloomberg Sch of Publ Hlth, Baltimore, MD, US

Primary Causes of Mortality in HIV Discordant Zambian Couples
Philip J Peters
Rwanda-Zambia HIV Res Group

Late Breaker -- National HIV Prevalence and BED HIV Incidence Estimates: South Africa 2005
Thomas Rehle
Human Sci Res Council, Cape Town, South Africa

Late Breaker -- Prevention of Rectal SHIV Transmission in Macaques by Tenofovir/FTC Combination
Walid Heneine
CDC, Atlanta, GA, US

Late Breaker -- Impact of HSV2 Suppressive Therapy on HIV-1 Genital Shedding and Plasma Viral Load: a Proof of Concept Randomised Double-Blind Placebo Controlled Trial (ANRS 1285 Trial)
Nicolas Nagot
London Sch of Hygiene & Tropical Med, UK

Late Breaker -- Association between Genital Schistosomiasis and HIV in Rural Zimbabwean Women
Eyrun F Kjetland
Ctr for Imported and Tropical Diseases, Ulleval Univ Hosp, Oslo, Norway

Investigation of Reports of Excessive False-positive Oral Fluid Rapid HIV Tests
Bernard Branson
Ctrs for Disease Control and Prevention, Atlanta, GA, US

Dramatic CD4+ T-Cell Depletion in the Intestine Is a Hallmark of SIV Infection in Natural Hosts
Ivona Pandrea
Tulane Natl Primate Res Ctr, Covington, LA, US

High Frequencies of Infected CD4+ T Cells in GI Tract Is Associated with Poor Mucosal Immune Reconstitution after HAART
Jason Brenchley
Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US

Initiation of HAART during Primary HIV-1 Infection Results in Better Restoration and Maintenance of Mucosal CD4+ T Cells
Satya Dandekar
Univ of California, Davis, US

Restoration of Memory CD4+ CCR5+ T Cells in the Gastrointestinal Tract during the Chronic Stage of SIV Infection Predicts Long-Term Non-Progression
Binhua Ling
Tulane Natl Primate Res Ctr, Covington, LA, US

CD4+ T-Cell Quantification within Gut Lamina Propria of HIV Patients after HAART
Jason Baker
Dept of Med at Univ of Minnesota

AIDS Defining CD4 T-Cell Levels Correlate with Expanded Coreceptor Usage (R5/X4) during Nonpathogenic SIVsm Infection of Sooty Mangabeys
Jeffrey Milush
Univ of Texas Southwestern Med Ctr, Dallas, US

CXCR4-Tropic Viruses Are Common among Antiretroviral-Treated Patients with Detectable Viremia and Associated with Lower Treatment-Mediated CD4 Gains
Peter Hunt
Univ of California, San Francisco, US

Late Breaker -- The Effect of HIV Subtype on Rapid Disease Progression in Rakai, Uganda
Oliver Laeyendecker
NIAID, NIH and the Johns Hopkins Med Inst, Baltimore, MD, US

Adherence to NNRTI-Based Regimens and Virologic Outcomes in HIV-Infected South African Adults
Jean Nachega
Johns Hopkins Univ, Dept of Intl Hlth, Baltimore, MD, US

Mortality and Causes of Death in Adults Receiving HAART in Senegal: A 7-Year Cohort Study
Eric Delaporte
Inst for Res and Devt and Univ of Montpellier, France

Rapid Scale-Up of Antiretroviral Services in Zambia: 1-Year Clinical and Immunologic Outcomes
Moses Sinkala
Zambian Ministry of Hlth, Lusaka, Zambia

Performance Characteristics of Non-CD4 based Criteria for Initiation of Antiretroviral Therapy in an Ambulatory Clinic Population in Phnom Penh, Cambodia
Chel Sarim
Natl Ctr for HIV/AIDS, Dermatology and STIs Ministry of Hlth Cambodia

Regimen Durability and Tolerability to 36 Months Duration on ART in Khayelitsha, South Africa
Andrew Boulle
Sch of Publ Hlth and Family Med, Univ of Cape Town, South Africa

When Are Adults in Resource-Constrained Settings most likely to Experience an HIV-Associated Illness following HAART Initiation and What Is It Related To?
Paula Braitstein
Univ of Berne, Switzerland

Tuberculosis among HIV-Infected Patients Receiving HAART: Long-Term Incidence and Risk Factors in a South African Cohort
Stephen Lawn
Desmond Tutu HIV Ctr, Univ of Cape Town, South Africa and London Sch of Hygiene and Tropical Med, UK

Prevalence of HIV and Undiagnosed Tuberculosis in a Periurban Community in South Africa
Linda-Gail Bekker
The Desmond Tutu HIV Ctr, Univ of Cape Town, South Africa

HIV Infection of Non-Dividing Cells
Michael Emerman
Univ of Washington Sch of Med and Fred Hutchinson Cancer Res Ctr, Seattle, US

Restriction of Retrovirus Replication
Jonathan Stoye
Natl Inst for Med Res, Med Res Council, London, UK

Evolution of Intrinsic Immunity against Retroviruses in Primate Genomes
Harmit Malik
Fred Hutchinson Cancer Res Ctr, Seattle, US

New Insights into the Antiviral Action of APOBEC
Warner Greene
Gladstone Inst, Univ of California, San Francisco, US

Antiretroviral Therapy to Prevent Sexual Transmission of HIV
Myron Cohen
Univ of North Carolina at Chapel Hill, US

Beyond Condoms: Chemical and Physical Barriers to Protect Women from HIV
Sharon Hillier
Univ of Pittsburgh Sch of Med, Magee-Womens Hosp,PA, US

Vaccines to Induce CTL Responses to HIV in Immunocompetent Individuals: State of the Field
Lawrence Corey
HIV Vaccine Trials Network, Fred Hutchinson Cancer Res Ctr, Seattle, US

HIV Voluntary Testing and Counseling (VCT) Divides, But It Should Unite
Thomas Coates
Univ of California, Los Angeles, US